ASSESSMENT OF IMPORTANCE OF PROGESTERONE RECEPTOR AS PREDICATIVE AND PROGNOSTIC FACTOR IN TREATMENT OF PATIENTS WITH BREAST CANCER

Lebedeva O.I.

137 patients with breast cancer were evaluated. The median age of these patients was 53.6years (range 26–73 years). They were separated into three groups, depending from receptor pattern of tumor: ER+ PR+ (n = 72), ER+ PR- (n = 23) and ER- PR- (n = 42). The median age of patients of each group did not differ. Considerable differences in dimensions of primary tumor, differentiation stage, 4-year survival rate of patients in groups ER+ PR+ and ER+ PR- were not revealed. In group ER+ PR- as compared with ER+ PR+ the percentage of lesion of lymph nodes was some lower, rarely were diagnosed distant metastases, period without recurrence was 4 month longer. At the same time in group ER+ PR+ more organ-preserving operation was carried out than mastectomy. It may be associated with smaller tumor size. After organ-preserving surgical interventions the local relapse appeared more in the group ER+ PR-. In postmenopausal period mortality till 1 year and 4-year survival rate practically were the same in the groups ER+ PR+ and ER+ PR-. Thereby the significance of progesterone receptor as independent prognostic and predicative factor was not determined.