EFFECT OF CRYODESTRUCTION WITH AUTO-VACCINATION ON SOME PARAMETERS OF CELLULAR AND HUMORAL IMMUNITY IN BREAST CANCER

Taschiev R.K., Abramenko I.V., Shlyakhovenko V.A., Ashraf Avad El Karim

Tumor cryodestruction with subsequent surgery and cryoautovaccination was performed in 22 breast cancer patients, including 5 at stage IIa (T1‑2N0‑1M0); 9 at stage IIb (T2‑3N0‑1M0), 7 at stage IIIa (T2‑3N2M0); and 1 at stage IIIb (T4N0‑3M0). Patients tolerated the combined treat‑ ment without general and local side effects and resulted in a significantly decreased concentration of СА15‑3 an‑ tigen in the blood serum, increased helper‑to‑suppres‑ sor ratio, tendency to increased numbers of CD3+‑ and CD4+‑T lymphocytes, development of delayed‑type hy‑ persensitivity and appearance of serum antibodies to the vaccine’s components. Over the follow‑up period (12 to 28 months) all patients were alive with no signs of re‑ lapse. These findings suggest that it is promising to con‑ tinue investigation in this direction.



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