CONTENTS OF ADIPONECTIN AND LEPTIN IN PERIPHERAL BLOOD SERUM OF BREAST AND ENDOMETRIAL CANCER PATIENTS WITH OBESITY

Nesina I.P.¹, Zadvornyi T.V.¹, Nespryadko S.V.², Kliusov O.M.³, Buchynska L.G.¹

• ¹R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine
• ²National Cancer Institute, Kyiv, Ukraine
• ³Kyiv City Clinical Oncology Center, Kyiv, Ukraine

Objective: to determine the relationship between adiponectin (Ad) and leptin (Lep) in periphe­ral blood serum (PBS) of breast (BC) and endometrial cancer (EC) patients with the presence of obesity and clinically pathological parameters. Materials and methods: PBS of 35 BC patients of the І–ІІ stage of the disease (average age — 57.9 ± 4.1 years), 34 ЕC patients І–ІІ stage of the disease (average age — 58.8 ± 4.5 years) and 13 conditionally healthy persons (mean age 44,9 ± 4,3 years) that were used as a control. Me­thods: anthropometrical, clinical, morpholo­gical, enzyme-linked immunoaassay (ELISA), statistical. Results: found that in PBS of BC and PE patients there are an imbalance in the content of adipose tissue hormones Ad and Lep in comparison with the rates of conditionally healthy persons. In BC patients with basal subtype tumors, the ratio of Ad/Lep in the PBS was lower (0.05) than in patients with tumors of the lumen A subtype (0.17). It was shown that for obese (body mass index ≥ 31.0 kg/m²) and hypertension (blood pressure ≥ 140/80) in PBS with BC and EC patients the Lep concentration was significantly higher (44.5 ± 5.9 and 45.6 ± 4.7) than in patients with normal weight and without hypertension (res­pectively 9.7 ± 3.5 and 10.6 ± 3.9, p < 0.05). At the same time, the ratio of Ad/Lehr in the PBS of BC patients with obesity and hypertension was 7.3 times lo­wer (0.15) than in patients with BC patients with normal weight and arterial pressure (1.1). In the group of EC patients with these changes were more pronounced, amounting respectively to 0.04 and 0.4. Conclusions: an increase of Lep concentration in the PBS of the examined patients was connected with obesity and hypertension. The reduction of the Ad to Lep ratio in PBS of BC patients are associated with a basal molecular subtype and such signs of aggressiveness of the tumor process as a low degree of differentiation, a high proliferative potential, and in EC patients, a low degree of differentiation and a profound invasion of the tumor in myometrium. Components of metabolic syndrome can determine the biological peculiarities of hormone-dependent tumors of the female reproductive system.