COMPARATIVE EVALUATION OF THE EFFICACY OF NEOADJUVANT POLYCHEMOTHERAPY AND PRE- SURGERY LARGE-FRACTION RADIATION THERAPY IN TREATMENT OF BREAST CANCER STAGES II/III PATIENTS

Efetov V.M., Dylenok I.N.

Comparative evaluation of the efficacy of neo- adjuvant polychemotherapy (NPCT) and large-fraction radiation therapy (RT) in 254 breast cancer (BC) patients at stages II or III (Т1-4N0-2M0) was performed. The groups were established by way of randomization. It was shown that involution of tumor does not appear in 31.8 ± 3.8% patients after NPCT and the 2–5 relapse-free and survival rates were significantly higher after large-frac- tion RT. During the follow-up period, the percentage of patients with remote metastases was two times higher af- ter NPCT compared to large-fraction RT; i.e. 26.7% and 13.0% respectively (р < 0.05). The authors attribute the less favorable remote results of NPCT to the delay (by 3 to 4 months) in the surgical treatment.