GENETIC COMPONENT AS A BREAST CANCER FACTOR IN VARIOUS ETHNIC GROUPS OF THE CRIMEAN POPULATION

A clinical/genealogical and genetic mathematic study of 57 healthy subjects and 214 breast cancer (BC) patients showed that malignant neoplasm is more frequent in immediate (degree 1) relatives of BC patients in both Crimean Tartar and Slavic populations compared to the general population (10.44% versus 7.36% respectively). In the Crimean Tartar population, genetic burden plays a more considerable role in BC frequency compared to the Slavic population. This conclusion is based on a number of findings, including: younger age of BC manifestation in both probands and their relatives (53.4 ± 3.6 and 46.5 ± 11.2 in Tartars versus 59.8 ± 1.9 and 54.9 ± 8.3 in Slavs), higher frequency of BC in relatives (48.3 ± 11.1 versus 25.6 ± 6.6% respectively), higher correlative share of genetic factors in the development of malignancy (genetic component: 58.5 against 44.5%, р < 0.05), and a tendency towards higher frequency of malignancy in family members of Tartar probands (38.67 against 35.20%, р > 0.05).