THE PROGNOSTIC SIGNIFICANCE OF MICROVESSEL DENSITY FOR SEROUS OVARIAN CANCER PATIENTS

Nesina I.P., Romanenko O.V., Grinkevych V.M., Svintsitskiy V.S.

Current study has demonstrated that microvessel density (MVD) in ovarian serous carcinomas was very heterogeneous, especially in G3 adenocarcinomas. Patients who lived less than 5 years were shown to have significantly increased MVD and p53 expression and decreased estrogen receptors (ER) expression compared to those who lived longer after the operation. It has also been established that metastases occur on the background of high ER expression. The obtained data prove that the study of MVD, p53 and ER expression in serous ovarian cancer is very perspective and can be used as prognostic markers of this disease course.