HUMAN PAPILLOMAVIRUS ONCOPROTEIN E6 EXPRESSION IN EPITHELIUM OF THE UTERINE APPENDAGES WITH OVARIAN CANCER AND GENETIC PREDISPOSITION TO IT
Bilyk E.А., Buchynska L.G., Polychshuk L.Z., Pejovic Т.
Complex morphological and immuno- histochemical study of adnexa uteri in 20 women with genetic predisposition to ovarian cancer (OC) and 55 OC patients was carried out. The presence of HPV 16/18 E6 oncoprotein in epithelial lining of fallopian tubes, ovarian surface epithelium, granulose cells of follicules, epithelium of follicular cysts and endothelial cells was revealed in 60% of women at high risk of developing OC. Tumor cells of 16,3% of OC patients were also positive for HPV 16/18 E6 oncoprotein. Expression of tumor suppressor protein p53 was absent in HPV-positive ovarian tissues in women at high risk of developing ovarian cancer and was significantly lower in HPV-positive OC compared to HPV-negative tumors. It is assumed that papillomavirus infection can be an addition exogenous inductor of malignant transformation of ovarian epithelium.
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