VALUE OF TUMOR BIOMARKERS WITH THE DIFFERENT DRUG RESISTANCE PHENOTYPE FOR CURRENT OF DISEASE AT BREAST CANCER PATIENTS

Shpyleva S.I., Yurchenko О.V., Volkova K.D., Galakhin K.О.

Tumor drug resistance molecules (Pgp, GST), molecules of adhesion (E-cadherin, mucine (MUC1)), regulators of a cellular cycle (p53, Bcl2, Metallothionein), hormone receptors (ER, PR) expression have been investigated at 45 BC patients T2N0-1-2M0 stages by immunohistochemical assay. It was shown that drug resistance phenotype correlates with tumor aggressive current of disease, regional lymph node metastasis and reduced survival of BC patients. Drug resistance mechanism is important for BC current and only GST+ resistance phenotype significant for adverse BC prognosis. The change of BC patient’s tumor biomolecules expression during different drug resistance phenotype forming (Pgp or GST way) is not identical and GST way characterizes more aggressive current. Metallothionein expression is significant for reduced survival prognosis at BC patients.



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