RESULTS OF CHEMO AND THERMO RADIOTHERAPY IN OPERATED AND NONOPERATED PATIENTS WITH SOFT-TISSUE SARCOMA

Kurpeshev O.K., Zubarev A.L.

A combined treatment was administered in thirty six soft-tissue sarcoma (STS) patients with varying histological structures. Out of these 36 patients, 1 (2.8%)patient wasat stage I; 2 (5.6%) patients wereat stage II; 17 (47.2%) patients were at stage III; 4 (11.1%) patients were at stage IV; and the remaining 12 (33.3%) patients were withrelapsesof STS. A localizedformof STSwasdiagnosed in 29 (80.5%) patients; remote metastases were detected in 7 (19.4%) patients, including 4 (11%) patients with metastases to the lungs. In 23 out of 24 primarypatients, the dissemination of tumor was estimated as T2b. The patients were subjected toone cycle of neoadjuvant polychemotherapy (NAPCT) and hyper-fraction radiotherapy with local radiofrequency hyperthermia within 2 to 3 days. After thermoradiotherapy (TRT), the operable patients were exposed to one cycle of NAPCT and surgery with or without intraoperative radiation of the tumor bed. The patients who were not operated for any reason, were subjected to polychemotherapy (PCT) with 1 to 1.5 month intervals for aperiodof 6 months andwith 3 monthintervals during one year. It is shown that TRT does not lead to severe radiation responses and skin or subcutaneous fat lesions. Within one month after TRT, a partial regression was observed in 36.0% patients. Some patients after TRT combined with PCT showed a full regression. Overall relapse-free and metastases-free survival rates of non operabel patients with STS assessed based on the post-TRT time were 92.8; 88.6; and 90.0% respectively.