NEW APPROACH TO OPTIMIZING NONSURGERY TREATMENT OF PRIMARY NON-HODGKIN MALIGNANT LYMPHOMA OF THE STOMACH

Korobko V.B., Chorny V.O., Rozumiy D.O., Osinsky D.S., Tofan A.V., Boyko G.S., Gordiyenko K.P., Levkovska L.Y.

A schedule is proposed for treating primarynonHodgkin malignant lymphoma of the stomach (PNHLS) without any surgery intervention. Treatment begins with polychemotherapy (PCT) according to СНОР regime (6 courses). The first 4 courses ensure full regression and stable remission in 84.2% patients at stage І-E–ІІ-Е. The 5th and 6th courses are given at a 3-month interval for relapse prevention. In the absence of a full regression of PNHLS after 4 courses of PCT, radiation therapy (a total local dose of 30 Gy) can be added. Four to six weeks after the full regression, one course of recombinant alpha-2b interferon (30 million IU) is applied. The paper discusses the issues of tolerance and remote results of this therapy.