Р53, VEGF, AND CD34 EXPRESSION IN TUMOR TISSUES AND SURVIVAL OF PATIENTS WITH ADVANCED OVARIAN CARCINOMA

Expression of р53 and VEGF as well as microvessel density (MD) (bases on CD34 expression) was assessed in surgery material of patients with ovarian carcinoma (OC). Expression of the above-listed markers was shown to depend on the stage of disease and age of patients. It was established that assessed indicators are higher in OC patients of reproductive age compared to menopausal patients. The overall relapse-free survival was significantly less in the former (patients under 45 years of age) compared to the latter (patients aged 45 years and over). It was shown that р53 and VEGF expression as well as MD were lower in patients who lived more than 5 years compared to those who lived less than 5 years (regardless of age). The set of indicators assessed in this study is a promising predictor of the course of disease in OC patients.