THE WAYS TO IMPROVE DRUG THERAPY OF RECTAL CANCER PATIENTS WITH LIVER METASTASES:ADVANTAGES OF METRONOMIC REGIME OF CHEMOTHERAPY

Maksim’yak G.I., Bezdenezhnykh N.O.

The paper presented the experience of treat- ment patients (stages T1-4N0-2M1) with metronomic re- gime of chemotherapy. In this mode of treatment 168 pa- tients carried out using different schemes, which included cyclophosphamide, cisplatin and irinotecan in combination these drugs with interferon. Established that the developed scheme metronomic therapy prolong partial clinical effect, contribute to stabilization of the disease and increase over- all surviving of patients with metastases of colorectal can- cer that subject only symptomatic therapy. Manifestation of toxicity and side effects were minimal and did not ex- ceed 1 degree. Using of interferon in the schemes metro- nomic chemotherapy significantly increased their effective- ness. Drug therapy in new metronomic mode may be rec- ommended for patients with liver metastases of colorectal cancer under ineffectiveness of traditional drug treatment patterns and progression of tumor.