THE TREATMENT OF GASTROINTESTINAL TRACT STROMAL TUMORS (GIST)

Kolesnik E.A.

Reported data are of the pathogenesis and diagnosis of the stromal tumors of gastrointestinal tract (GIST) and the role of c-Kit mutation. The role and place of surgical treatment, radio- and chemotherapy and target therapy is discussing. Modern treatment conceptions of GIST, depending on pathogenesis, are presented. Results of main randomized trials of the efficiacy of the imatinib and sunitinib are presented.