MARKERS OF APOPTOSIS AND PROLIFERATION OF TUMOR CELLS IN THE DYNAMICS OF OVARIAN CANCER PROGRESSION
83 ovarian cancer (OC) patients were immunohistochemically examined to determine the proliferation markers Ki-67 and PCNA as well as apoptosis markers p53 and bcl-2 in the primary tumor nodes. It was found that Ki-67 index was in average 5.4% on the Ist stage; 10.2% on the IInd stage; 47.0% on the IIIrd stage and 45.5% on the IVth stage of the disease. It was shown that in tumor progression the number of cells that express p53 or bcl-2 significantly increases. The conclusion is in the tumor progression in the primary tumor nodes there is a possible selection of p53+ neoplastic cells with high proliferative activity and hyperexpression of bcl-2 oncoprotein.
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