HEREDITARY BREAST CANCER: CLINICAL, MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES

Datsyuk І.О., Deneka R.Ye., Smolanka І.І.

Comparative analysis of clinical and biological features in 58 patients with hereditary, family and sporadic breast cancer was carried out. The correlation between expression of BRCA1 and estrogen receptors, proliferative activity and age in patients was established. The specific biological features of tumors in patients with hereditary breast cancer suggest BRCA1 germ-line mutations and may be used to predict BRCA1 mutations status in relatives.



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