MICROHETEROGENEITY OF ALPHA ACID GLYCOPROTEIN IN NEOPLASM AND INFLAMMATORY PROCESSES

Steklenyova N.I., Brazaluk A.Z., Lytvyn K.Y.

Blood serum of 71 patients with neoplasm or inflammatory processes was tested for contents and glycosylation of alpha acid glycoprotein. Significantly (2 to 4 times) increased AAG levels were found in patients with acute inflammation and cancer. Changes in the structure of the AAP correlated with the nature of disorder. Patients with viral hepatitis and malignancies in the pancreaduodenal area featured a significant increase in the content of APP with polyantenna structures. At the same time, lack of AAP glycoform which is firmly linked with concanavallin A is a specific feature of mechanic biliousness caused by malignancies. PHA-L-linking capacity of AAP in out-patient pneumonia is considerably lower compared to both normal control and systemic inflammatory response syndrome.



No comments » Add comment