THE FLUOROURACIL PHARMACOKINETICS IN TUMOR AND NORMAL TISSUES OF PATIENTS WITH GASTRIC ADENOCARCINOMA

Stashkevych M.A., Khomutov E.V., Sidyuk A.V., Popovych Y.A., Popovych A.Y., Zynkovych I.I.

A comparative study of the pharmacokinetics of fluorouracil (FU) in tumor and normal (non transformed) tissues in 16 patients with gastric adenocarcinoma was car- ried out. In 2–60 min after intraarterial injection of FU sam- ples of tumors and normal tissues were selected, and there was determined concentration of FU and dihydropyrimidine dehydrogenase (DPD) activity. It is established, that in the tumor tissue concentration of FU decreases exponentially with the increase of time after its introduction (R = -0,74 at p = 0.01). It is marked the moderate correlation activity of DPD with the concentration of FU (R = -0.62 for p= 0,06) and DPD activity with time after the introduction of FU (R = 0,59 for p = 0,07). At the same time in the adjacent normal tissue all the above links are not available. Thus, in the tumor tissue there is a lack of individual peculiar- ities of the catabolism FU in different patients, which is not typical for normal, adjacent tissues.