FUNCTIONAL ACTIVITY OF IMMUNE CELLS OF INTACT MICE UNDER ITS INTERACTION WITH FERROMAGNETIC NANOPARTICLES IN VIVO AND IN VITRO

Vinnichuk U.D.

There was studied the effect of ferromagnetic (Fe3O4 stabilized with polydextran, particle size – 40– 60nm) on the immune system cells functional activity while direct interaction and after input into an animal organism. The objects of research were lymph nodes lymphocytes, peritoneal macrophages and peripheral blood neutrophils from Balb/c mice. It was shown that ferromagnetic nanoparticles dose-dependently change functions of these immune system cells. The changes had multidirectional nature which came out with suppression of lymphocytes proliferative response while input of nanoparticles into an organism and some stimulation of lymphocytes activity in direct influence of ferromagnetic; also activity of phagocytes changed, depending on conditions. ferent particle sizes in the nanometer and micrometer ranges: are we defenseless against nanoparticles? Int J Occup Environ Health 2010; 16 (4): 508–24. Chen BA, Jin N, Wang J, et al. The effect of magnetic nanoparticles of Fe(3)O(4) on immune function in normal ICR mice. Int J Nanomed 2010; 5: 593–9.Wang J, Chen B, Jin N, et al. The changes of T lymphocytes and cytokines in ICR mice fed with Fe(3)O(4) magnetic nanopar- ticles. Int J Nanomed 2011; 6: 605–10.Chekhun VF, Todor IN, Lukyanova NY, et al. The use of nanoferomagnetics to increase the cytotoxic effect of antitumor druds. Exp Oncol 2009; 31 (3): 163–7.Бережная НМ, Бобкова ЛП, Бейко ВА и др. Разнообразие вариантов гиперреактивности В-лимфоцитов при