ESTROGEN RECEPTORS EXPRESSION AND CLINICAL PECULIARITIES OF BREAST CANCER

Rate of distant metastases (M1) and positive nodes status (N1–N2) was analyzed in the moment of hospitalization of 1916 patients with breast cancer, including of 1309 with estrogen receptor-positive tumors. In 25 patients the level in the blood serum of some enzymes of exchange of carbohydrates and nucleosides was determined. It was shown that probability of distant metastases was significant higher at estrogen- negative tumors of women at the small sizes (T1–2) of tumor or at the stored menstrual function. Opposite, the metastases in regional lymphatic nodes were more frequently registered among women in a premenstrual period and with the expression of estrogen receptors. High levels of serum adenosine deaminase and lactate dehydrogenase, combining with the low serum activity of thymidine phosphorylase, can serve as indirect index of absence of estrogen receptors.