DIURNAL RHYTHMS, CIRCADIAN GENES AND MALIGNANT TUMORS

Shishko E.D., Gamaleia N.F., Minchenko A.G.

Data published on the association of tumori- genesis with circadian rhythmicity disruption are summarized. Principles of the biological clock molecular organization, the involvement of circadian genes in bioregulation processes, especially in the cell proliferation, are discussed. The circadian genes Per participation in cell responses to DNA alterations and the genes role as potential suppressors of tumor growth are analyzed.