EFFICACY OF IMMUNOTHERAPY DEPENDING ON THE TUMOR’S SUSCEPTIBILITY TO DOXORUBICIN (EXPERIMENTAL STUDY)

Belova O.B., Kirnasovskaya E.A., Rudenko D.F., Savinskaya I.G.

The paper presents findings of the study of the efficacy of various types of immunotherapy in mice with inoculated doxorubicin-resistant and doxorubicin- susceptible MC-rhabdomyosarcoma. Two autovaccines were used which were obtained with the help of different biotechnologies and adoptive immunotherapy utilizing LAK cells. It is shown that all types of immunotherapy were more efficient with respect to doxorubicin resistant tumor; efficacy of LAK therapy is more pronounced. Comparative assessment of the efficacy of autovaccines showed that non-immobilized vaccine is more preferable.