CURRENT APPROACHES TO THE DIAGNOSIS AND TREATMENT OF BREAST CANCER PATIENTS

The review presents current data on the diagnosis and treatment of the patients with primary operable breast cancer and focuses on the development of personalized approaches to the treatment strategy of this common disease. In the article, the authors present the results of clinical studies which confirmed the role of determining miRNAs expression not only for timely and complete but also for personalized treatment of patients. The marked heterogeneity of breast cancer and subtypes of the disease based on clinical, morphological, molecular, genetic, epidemiological and other approaches, as well as significant differences in risk factors suggest that the treatment strategy of patients with breast cancer has not been completely resolved. Nevertheless, the current level of knowledge about the molecular mechanisms of breast cancer origin and development, its sensitivity or resistance to various drugs and treatment modalities allows us to start the transition from averaged standard treatment regimens to treatment based on individual patient particularities and biological characteristics of the tumor. Moreover, deepening our knowledge of breast cancer biology could become a key to understanding local recurrence and distant metastases development after the radical treatment.