ROLE OF IMMUNE SYSTEM CELLS IN TUMOR MICROENVIRONMENT. II. INTERACTION OF THE IMMUNE SYSTEM CELLS WITH OTHER MICROENVIRONMENT COMPONENTS

According to the author’s opinion, the role of immune system in tumor microenvironment may be objectively highlighted only if its relation to other components of microenvironment is accounted. Respectively, the patterns of interaction of the cells of immune system with extracellular matrix, fibroblasts, endothelial cells as the main components of microenvironment, are discussed. Also, the possible ways of influence of altered metabolism of microenvironment on the functions of the cells of immune system allowing consider the hypothesis on their metabolic reprogramming, are presented.