IMMUNOLOGICAL CHANGES IN PATIENTS WITH BLADDER CARCINOMA
The blood counts of CD3+, CD4+, CD8+, CD16+, CD19+, and HLA-DR+ lymphocytes were determined before and after treatment of bladder carcinoma (BC) patients by way of: segmental resection (SR); SR with subsequent gamma telethepary (SR + GT); large-fraction pre-operative radiotherapy with subsequent SR and post-operative radiotherapy (LF-GT + SR + GT); transurethral resection with subsequent chemotherapy and radiotherapy (TUR + CT-GT). At the baseline, the study patients featured an increased relative count of CD8+ lymphocytes, decreased CD4/CD8 ratio, and decreased expression of HLA-DR antigens, i.e. markers of the activation of immunocompetent cells. Post-treatment analysis showed a tendency towards changes in all groups of immunological indicators compared to the baseline. The most adverse combination of tendencies in the changes of particular indicators was observed after SR or TUR + CT- GT. Decreased CD4/CD8 ratio and HLA-DR antigen expression after treatment was associated with a decreased relapse-free period and increased frequency of relapses.
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