WITH MYELOID METAPLASIA AT THE PERSONS SUFFERED FROM IONIZING IRRADIATION

Bebeshko V.G., Kabachenko I.N., Djagil I.S., Pleskach O.J., Belinskaja I.V.

Level of platelet-derived growth factor (PDGF-BB) in blood serum and bone marrow of patients, suffered from myelofibrosis with myeloid metaplasia (MMM) as result of Chernobyl accident (I group) and not exposed to irradiation people (II group) were determined by immunoassay. Control group (III group) consists of patients without haematological diseases and fibrosis process in bone marrow. the interaction between status megakaryocytic lineage and a level of PDGF-BB secretion in groups is analyzed. the aim of this is to evaluate the contribution of ionizing radiation (IR) and level of PDGF-BB in the pathomorphogenesis of MMM. Increase of PDGF-BB concentration in BM`s serum of patients with MMM comparing with those in the control group was revealed. Correlation between PDGF-BB contents and number of megakaryocytic in patients with MMM without blast proliferation was found. More higher PDGF-ВВ concentrations in BM`s serum in patients with MMM, suffered from Chernobyl accident, in comparing with those in patients of II group, are associated with increase of quantity of young forms of megakariocytes, expressed by proliferation of hemopoietic cells-precursors in BM.