PHARMACO-TOXICOLOGICAL, PHYSICAL-CHEMICAL AND ANTICANCER PROPERTIES OF FERROMAGNETIC IRON NANOPARTICLES (EXPERIMENTAL STUDY)

Mosienko V.S., Kuschevska N.F., Boichuk I.V., Kurtseitov L.K., Karnaushenko O.V., Dasiukevich O.J., Verbinenko A.V.

The characteristics of original feromagne- tic iron nanoparticles (FIN), obtained in A.V. Duman- sky Institute of colloid chemistry and water chemistry of the NAS of Ukraine: the shape, the dimensions and geo- metry of FIN; their toxicity; penetration (per os adminis- tration) in the tissues of different organs and tumors; in- fluence on activity of mitochondrial FeS-protein N-2; cytochrome P450 (g=2,25) activity; the generation of su- peroxide and NO-radicals in the tissues of liver, kidneys and tumors and in neutrophils of peripheral blood; and activity of FIN of model tumors strains (lymphoma R388, Ehrlich ascites cancer, metastatic Lewis lung carcinoma) were studied. The obtained data testify about the prospects of further FIN research with a view to develop technology of their clinical application.