MODIFICATING EFFECT OF UBIQUINONE, AND COMPLEX OF PRECURSORS AND MODULATOR OF ITS BIOSYNTHESIS ON LIVER’ AND HEART’ MITOCHONDRIA UNDER DOXORUBICIN TREATMENT

Kuchmenko О.B., Petukhov D.М., Luk’janchuk E.V., Delemenchuk N.V., Donchenko G.V.

The important part of doxorubicin toxici- ty is an activation of MMPs, which leads to increased destruction of extracellular matrix. The mitochondrial electron-transport chain function was found to be im- paired in animals treated with doxorubicin. The decrease in CoQ radical – ubisemiquinone – level was found in organs of animals treated with doxorubicin in therapeu- tic dosage. The treatment by ubiquinone and complex of precursors of modulator of ubiquinone biosynthesis in parallel to doxorubicin leads to significant decrease in tissue MMPs activities, increase of ubisemiquinone content and normalization of mitochondrial electron- transport chain function, which leads to notable reduc- tion of doxorubicin toxicity.



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