DISEASE HODGKIN’S: COURSE AND PROGNOSIS DURING THE PREGNANCY

Ogorodnikova N.P., Kapinos A.V., Vovchenko I.V., Dekhtyar T.A., Osinsky D.S., Gorbatyuk T.A., Timovska Yu.A., Voytko N.L., Klyusov A.N.

The data of supervision of 17 treated patients with Hodgkin’s lymphoma (HL), at which on the different stages of disease flow pregnancy came with subsequent delivery, are presented. HL developed during pregnancy or after delivery, has the same clinical parameters as in nonpregnant women. In II and the III trimester of pregnancy a question about the antineoplastic treatment is decided individually for each patient. In those cases, when to postpone its beginning to delivery is not possible, therapeutic strategy must not differ from traditional for unpregnant women. In our supervision in 11 cases of HL was diagnosed in II–III trimesters, treatment taking into account all international recommendations was conducted after delivery In 6 cases pregnancy developed after primary treatment of HL on the stage of proof recurrence. For the fetus in analyzed by us 17 cases the negative consequences were not marked. From literature data they meet rarely, except for those clinical situations, when chemotherapeutic treatment is carried out during the I trimester of pregnancy or used radiotherapy. Presently all patients are living (term of supervision from 1 to 10 years); 15 —from them without the signs of relapse, 2 — in the period of remission after antirecurrent treatment. All children (8 boys and 9 girls) are practically healthy, develop without rejections