RS6449182 CD38 GENE POLYMORPHISM AND THE RISK OF CHRONIC LYMPHOCYTIC LEUKEMIA DEVELOPMENT

Bilous N.I., Chumak A.A., Martina Z.V., Filonenko I.A.

The aim of paper is evaluate the risk of chro- nic lymphocytic leukemia (CLL) depend on rs6449182 CD38 gene polymorphism. It was observed 249 CLL pa- tients and 238 age- and sex-matched controls. rs6449182 CD38 gene polymorphism was determined by polymerase chain reaction with restriction of reaction products. The number of polymorphic allele homozygotes (GG genotype) was increased in subgroup of rural CLL patients (24,4%) comparing with urban CLL patients (10,1%, р = 0,006) and controls (6,3%, р = 0,0001). The assumption was made concerning a possible association of rs6449182 CD38 gene polymorphism and the risk of CLL under in- fluence of negative agricultural factors. On the other hand, no data of association of rs6449182 CD38 gene polymor- phism and the CLL risk in urban CLL patients found.