GELATINASE A AND B IN ONCOHEMATOLOGICAL DISEASES

Gordiyenko Y.A., Nikolayenko-Kamishova T.P.

In the review the structure and function, the mechanisms of regulation of synthesis and activity of gelatinase A and B in blood cells at different stages of hemopoiesis are discussed. The data about the role of gelatinase in pathogenesis of cancer diseases of blood and lymphoid tissues are summarized. The possibility of their use as diagnostic and prognostic markers and the perspectives of use of natural and synthetic inhibitors of gelatinase as therapeutic agents are considered.