IMMUNOSTIMULATORY CPG DNA: PROSPECTS OF CLINICAL APPLICATION IN ONCOLOGY

Olishevskiy S.V., Kozak V.V., Yanish Y. V., Rybalko S.L.

The review presents information about the new promising area in tumor immunotherapy, i.e. application of DNA enriched with non-methylated CpG-motives. Data is presented on the immunostimulatory characteristics of CpG DNA and way sofcell signaling, as well as about classification ofsynthetic CpG-oligodeoxydeoxynucleotides(CpG-ODN). The prospects for application of CpG-ODNforimmunother- apy of patients with malignant neoplasm are discussed.



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