FEATURES OF ARCHITECTONICS OF COLLAGEN STRUCTURES IN TUMORS OF BREAST CANCER PATIENTS WITH DIFFERENT MANIFESTATIONS OF STROMAL REMODELING

Naleskina L.A., Lukianova N.Yu., Zadvornyi T.V., Kunska L.M., Chekhun V.F.

In recent years, desmoplastically altered connective tissue of the tumor stromal component is believed to be the most important driving force of tumor progression in patients with breast cancer (BC) that is due to type I collagen, which is associated with tumor cell metastasis and the adverse course of the disease. Aim: to identify some features of the architecture of collagen structures in the tumors of invasive ductal BC with the different ratio of epithelial and stromal components and to establish the relations between the features and clinical and pathological characteristics of the patients. Object and methods: the histological preparations of 69 patients with BC stained with picrofuchsin by van Gieson’s method were analyzed. The obtained results were compared with the clinical and pathological characteristics of the patients. Results: it is shown that the most pronounced rearrangements of the architecture of fibrous structures, namely collagen fibers, occur in the group of neoplasms with a predominance of desmoplastically altered connective tissue: an increase in the mass of collagen structures, in its density and the width of the layers, their alignment, rectilinear orientation, elongation of fibrous structures. The comparison of the obtained data in the selected groups of tumors of BC patients with clinical and pathological features of the disease revealed several patterns that are associated with the proliferative potential of the tumors, their receptor status, molecular subtype, age, stage of the disease and presence of regional metastases. Conclusion: on the material of patients with the invasive ductal BC, the results of morphological and clinical-pathological comparisons indicate that the tumor process depends not only on the epithelial component of the tumor but also, to a greater extent, on the characteristics of connective tissue including its desmoplastic rearrangement and changes in the collagen architecture.



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