LYMPHANGIOGENESIS AND TUMOR METASTASIS
Current knowledge concerning both molecular and cellular mechanisms controlling tumor associated de novo formation of lymphatic vessels is analyzed. The special attention is focused on regulation of lymphangiogenesis by VEGFC/D and their involvement in lymphatic metastasizing. The principal techniques used for the assessment of VEGFC and VEGFD content as well as the density of the lymphatic vessels are outlined. The prognostic/predictive potential of the abovementioned parameters in the patients with different solid tumors is also discussed.