ROLE OF IMMUNE SYSTEM CELLS IN TUMOR MICROENVIRONMENT. I. CELLS AND CYTOKINES — THE COMPONENTS OF INFLAMMATION
In the review, analysis of literature data on the role of a number of cells of immune system (macrophages, neutrophils, mast cells, eosinophils), and cytokines and also other biologically active compounds secreted by these cells, in the formation of tumor microenvironment is presented. Realization of mechanisms that are used for participation of many cells of immune system for stimulation of tumor growth, and the role of hypoxia for polarization of functions of immune system cells, in particular, macrophages, and their remodeling are emphasized. The special attention has been paid to the role of some cells in the formation of immunosuppression. In particular, the role of monocyte-dependent suppressor cells (MDSC), CD4+CD25+FOXP3+ T-lymphocytes, Th17 etc, is discussed in detail.