ANTITUMOR AND MODIFYING EFFECTS OF DRUG FROM THE GROUP OF ALKALOIDS ALKILATED BY THIOPHOSPHAMIDE FROM CELANDINE (EXPERIMENTAL SUTUDY)
The antitumor and modifying activities of alkilated alkaloids fromcelandine(AAl) have been studied in the experiment swithrat transplanted tumors, inparticular Guerin carcinoma and sarcoma-45. The obtained results have displayed the presence of antitumor activity of AAl, especially against thesoft-tissuetumors. Local hyperthermia has enhanced the antitumor effect of AAl. It was observed the significanten hancement of anti tumor action of platidiam used at a small dose by its application in combination with AAl with out obvious in crease of cysplatinum side effects. The original biological effect of AAl was observed in our study. It wasdisplayedina«conservation» of growthof some tumors after the inhibition of their growth due to AAl application. Moreover, long-term coexistence of tumor and organism without features of intoxication has been observed. This phenomenon was accompanied with the sign if i cant increase of life span of tumor-bearing animals.
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