TUMOR HETEROGENEITY — DYNAMICAL STATE

Sherban S.D.

The paper presents the results of the analysis of literary data on the tumor heterogeneity. Phenotypic, genetic and epigenetic mechanisms of heterogeneity are considered. Its importance for the biology of populations of tumor cells and the sensitivity of tumors to therapeutic treatment are discussed. associated enzymes in drug response. Oncol Res 1997; 9: 295–302 van Cutsem E, Kang Y, Chung H, et al. Efficacy results from the ToGA trial: A phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (GC). J Clin Oncol 2009; 27: Abstr 4509. Фильченков АА. Визуализация и оценка апоптоза, вызванного противоопухолевой терапией:клинические перспективы. Онкология 2011; 13 (4 (50)): 266–77. Symmans WF, Volm MD, Shapiro RL, et al. Paclitaxel-in- duced apoptosis and mitotic arrest assessed by serial fine-needle aspiration: implications for early prediction of breast cancer re- sponse to neoadjuvant treatment. Clin Cancer Res 2000; 6: 4610-7.