LABORATORY DIAGNOSTICS OF HAIRY CELL LEUKEMIA

Vyhovska Y.I., Mazurok A.A., Lebed H.B., Tsiapka O.M., Pelenyo N.V., Zotova O., Vyhovska O.Y.

Based on the analysis of results of laboratory research in 87 patients a set of initial diagnostic features of hairy cell leukemia (HCL) has been stated. There has been defined a diagnostic value of occurrence of lympho- cytes with definitive morphology – hairy cells (HC) in peripheral blood and/or bone marrow, hemocytopenias (in 78.6% of patients), results of cytological and histolog- ical research of bone marrow (infiltration of HC, reticu- lar fibrosis), activity of tartrate-resistant acid phospha- tase in lymphocytes, immunophenotype characteristics of tumor lymphocytes (pan-B+, CD23–, CD5–, CD10–, CD25+, CD11c+, CD103+). Additional diagnostic crite- rion is a high expression level on HC of Thomsen-Frie- denreich antigen, which is detected with the help of pea- nut lectin (PNA). Clear differences of laboratory signs of HCL in younger patients (≤40 years of age) and old- er patients (>40 years of age) are absent.