GEMCYTABIN IN TREATMENT OF DISSEMINATED NON-SMALL CELL CARCINOMA OF LUNG WITH METASTASES IN THE BRAIN

Zakharychev V.D., Semivolos A.V., Sovenko V.M.

Findings are reported of a clinical study of the efficacy of chemoradiation therapy of patients with non-small cell carcinoma of lung with metastases in the brain. It is for the first time shown that irradiation of brain metastases with simultaneous chemotherapy with gemcytabin and platinum derivates provides a pronounced therapeutic effect. All the patients with metastases of glandular neoplasm showed positive results in the form of a full or partial regression of the tumor. The remission period lasted for 2 to 14 months (6 months on average). These findings provide grounds for a preliminary conclusion that gemcytabin exerts a radiation-sensitizing effect that helps overcome the hematoencephalic barrier.