K.I. Bardakhivska, V.V. Sarnatskaya, B.I. Gerashchenko, V.G. Nikolaev

R.E. Kavetsky Institute of Experimental Patholohy, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine


Summary. Development of malignant neoplasms is a serious pathological condition accompained by a significant body intoxication. Complex application of surgery, radiation and chemotherapy greatly improves the results of treatment of the patients with cancer, however, their toxic effects are enhanced that manifested as suppression of hematopoesis, immunosupression, nephrotoxicity, hepatotoxicity, cardiotoxicity. Enterosorption using highly active carbon sorbents is one of the perspective methods of overcoming endotoxicosis caused by systemic intoxication. The results of the study obtained on laboratory animals, namely on mice with Leweis lung carcinoma, rats with Geren’s carcinoma treated with cisplatin, rats treated with melphalan, doxorubicin, as well as irradiated rats, showed excellent efficiency of carbon enterosorbents in reducing the toxic manifestations of radiation and chemotherapy. The enterosorbents showed a myeloprotective action, lead to significant improvement of some haematological and biochemical parameters of blood and reduced manifestations of oxidative stress and the level of endogenous intoxication.  

Keywords: oncological pathology, enterosorption, cytostatics, radiation injury, myelosupression, oxidative stress, cardiotoxicity, carbon enterosorbent.



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